Editor Profile
Dr. Vipin Kumar Yadav, Ph.D.
Postdoctoral Researcher
Present
H. Lee. Moffitt Cancer Center
Florida
United States
Dr. Vipin K. Yadav is a scientist in the Department of Malignant Hematology at the H. Lee Moffitt Cancer Center, where his research bridges molecular biology and computational approaches to advance precision medicine in hematologic malignancies. His work focuses on unraveling the molecular and regulatory networks that drive disease progression and therapeutic resistance in myeloid neoplasms, including myelodysplastic syndromes (MDS), chronic myelomonocytic leukemia (CMML), and acute myeloid leukemia (AML). By integrating high-throughput genomics, transcriptomics, and computational modeling, Dr. Yadav aims to identify actionable targets and design mechanism-based therapeutic strategies. Dr. Yadav’s scientific journey began during his doctoral training at the CSIR-Indian Institute of Toxicology Research, where he investigated autophagy dynamics in KRAS-driven tumorigenesis. His research revealed compensatory interactions among macroautophagy, chaperone-mediated autophagy (CMA), and chaperone-assisted selective autophagy (CASA), highlighting complex degradative networks that sustain tumor homeostasis. This work sparked his enduring interest in the regulatory potential of post-translational modifications (PTMs) in cancer biology. In his postdoctoral role, Dr. Yadav explored the role of protein nitrosylation in therapeutic resistance in melanoma. He demonstrated that targeting nitrosylation re-sensitizes NRAS-mutant melanoma cells to MEK inhibitors and induces a vaccine-like anti-tumor immune response, underscoring the translational impact of PTM-driven signaling. At Moffitt, he has expanded his expertise to hematologic malignancies, employing integrative computational and molecular approaches to dissect transcriptional and post-transcriptional dysregulation. His current research investigates the interplay between granulocyte-monocyte progenitors (GMPs) and the long non-coding RNA MALAT1 in MDS and CMML pathogenesis, aiming to define how MALAT1-mediated transcriptional control influences progenitor cell fate and therapy resistance. Dr. Yadav’s long-term vision is to leverage computational pathology and systems biology to decode complex regulatory networks and translate these insights into targeted interventions that improve survival and quality of life for patients with hematologic cancers.
- Computational Modeling of Hematologic Malignancies
- Systems biology approaches to decode regulatory networks in myeloid neoplasms (MDS, CMML, AML).
- Integrative Multi-Omics Analysis
- High-throughput genomics and transcriptomics integration for precision medicine in hematologic cancers.
- Post-Translational Modifications in Cancer Biology
- Computational and molecular dissection of PTM-driven signaling and therapeutic resistance.
- Regulatory Network Dynamics in Disease Progression
- Modeling transcriptional and post-transcriptional dysregulation in malignant hematopoiesis.
- Long Non-Coding RNAs and Cell Fate Decisions
- Computational analysis of lncRNA-mediated transcriptional control (e.g., MALAT1) in progenitor cell differentiation.
- Mechanism-Based Therapeutic Strategy Design
- Predictive modeling to identify actionable targets and optimize treatment responses.
- Computational Pathology for Precision Oncology
- AI-driven approaches to correlate molecular signatures with histopathological features.
- Autophagy and Degradative Network Modeling
- Systems-level analysis of autophagy pathways and compensatory mechanisms in tumor homeostasis.
- Immune Response Modeling in Cancer Therapy
- Computational frameworks to study PTM-driven immune modulation and vaccine-like responses.
- Data-Driven Biomarker Discovery
- Machine learning and network-based approaches for prognostic and predictive biomarker identification.
- Vipin K. Yadav, et al. Quantitative Proteomics of Nitrosylated Proteins in Melanoma using the Biotin-Switch Technique Combined with Tandem Mass Tag Labeling. Bio-protocol (2025).
- Vipin K. Yadav, et al. Melanin-Driven Delayed CPD Formation Is Independent of Melanin Biosynthesis Pathway. Journal of Investigative Dermatology (2025).
- Jyoti Srivastava*, Vipin K. Yadav*, et al. Blocking Nitrosylation Induces Immunogenic Cell Death by Sensitizing NRAS-Mutant Melanoma to MEK Inhibitors. Cancer Research (2025). (equal contribution*).
- Jyoti Srivastava, Vipin Kumar Yadav, et al. Abstract 235: Targeting NOS sensitizes the NRAS-mutant melanomas to MEK inhibition and induces immunogenic cell death. Cancer Research (2025).
- Srivastava J, Young MM, Yadav VK, et al. The role of Acetyl zingerone and its derivatives in inhibiting UV-induced, incident, and delayed CPDs. Antioxidants (2023).
- Yadav VK, Awasthi P, Behl R, Kumar A. HSc70 interactome reveals a major role of macro autophagy in K-Ras-driven cancer. Journal of Proteomics (2022).
- Awasthi P, Srivastava AK, Yadav VK, et al. Proteome Profiling of Phosphatidylinositol-5-phosphate 4-kinase type 2A and 2B knockdown cells identify modifications in key regulators of cell homeostasis and genome integrity. Genome Instability & Disease (2022).
- Yadav VK, et al. Long noncoding RNAs in intestinal homeostasis, regeneration, and cancer. J Cell Physiol (2021).
- Yadav VK, et al. Detection of UV-Induced Thymine Dimers. Genotoxicity Assessment (2019).
- Awasthi P, Yadav VK, et al. Ataxia Telangiectasia and Rad3-Related (ATR). Encyclopedia of Signaling Molecules (2017). (*Equal contribution).
