Research Article 10.5281/zenodo.21860321

Machine Learning-Based Classification of Tuberculosis Using Whole-Blood Gene Expression Profiles: A Multi Cohort Transcriptomic Study with SHAP-Based Interpretability

Adeel Asghar

Background: Tuberculosis diagnosis remains a practical challenge in high-burden settings, where available tests have well-known limitations around sensitivity, cost, and turnaround time. Whole blood gene expression profiling offers a non-sputum-based alternative approach, but…...

Research Article 10.5281/zenodo.21860514

Pilot Study on the Relation Between Orthodox Spirituality, Inclusion and Health, In a Sample of Wheelchair Users

Konstantinos N. Papanikolaou

Persons with disabilities have significantly lower life expectancy compared to the general population. Concerning wheelchair users, the main causes of premature death are heart attack and cancer. The main risk factors are physical inactivity and obesity. Factors such as depression and social…...

Perspective 10.5281/zenodo.21861772

When Food Becomes a Crown: A Reflection on Luxury Agriculture, Entitlement, and the Ethics of Nourishment

Chee Kong Yap

Encounters with everyday commodities can sometimes expose deeper structural and ethical tensions within modern food systems. This reflective paper examines a personal encounter with an ultra premium watermelon priced beyond ordinary affordability and marketed as the sole fruit matured on a plant…...

Review Article 10.5281/zenodo.21845732

Beyond DNA: Human Microbiome Signatures in Forensic Science—Current Advances, Challenges, and Future Perspectives

Vishal Dhayal

Background: Forensic microbiomics is an emerging discipline that investigates the use of human associated and environmental microbial communities as complementary sources of forensic evidence. The recent development of next-generation sequencing, metagenomics, bioinformatics and…...

Research Article 10.5281/zenodo.21862134

Anticonvulsant, Antioxidant, And In Vitro Cytotoxicity Activities of Leucaena leucocephala (Lam.) de Wit (Fabaceae) Leaf Methanol Extract

Cletus Anes Ukwubile, Amina Ismail Chinda, Anietie Eyo Robert, et al.

Although Leucaena leucocephala has long been used for its hepatoprotective, anticonvulsant, antioxidant, and anticancer properties, there has been no rigorous pharmacological validation. The anticonvulsant, antioxidant, and in vitro cytotoxic activities of L. leucocephala leaf methanol extract…...

Case Report 10.5281/zenodo.21948198

Diagnosing Excessive Irrigation Fluid Intravasation During Operative Hysteroscopy: A Case Report

Na Yeon Kim, Kyu Nam Kim

Excessive irrigation fluid intravasation is a rare but potentially life-threatening complication of operative hysteroscopy.

A 46-year-old woman underwent hysteroscopic endometrial polypectomy under general anesthesia using normal saline as the uterine distension medium. During…...

Case Report 10.5281/zenodo.21852173

Vildagliptin-Induced Thrombocytopenia: A Case Report with Pharmacovigilance Perspective

Rahul Garg

Vildagliptin, a Dipeptidyl Peptidase-4 (DPP-4) inhibitor widely used in type 2 diabetes mellitus, is generally considered well-tolerated. We report a case of a 62-year-old woman who developed progressive, isolated thrombocytopenia approximately ten months after initiating vildagliptin 50 mg…...

Research Article 10.5281/zenodo.21860443

Comparative Study of Modified Boey’s Score and Mannheim Peritonitis Index in Predicting Outcome of Perforated Peptic Ulcer with Diffuse Peritonitis

Adeel Asghar

Background: Perforated Peptic Ulcer (PPU) complicated with diffuse peritonitis despite all advances of diagnosis and surgical care. The timely and precise identification of prognosis is one of the most key issues to optimize peri-operative management. In this study, the Modified…...

Research Article 10.5281/zenodo.21862830

A Method for Quantifying the Relative Level of Potential Invasiveness of Invasive Alien Plants

Xiaoxuan Geng, Ruike Zhang, Yizhuo Du, et al.

Quantitative assessment of invasiveness serves as a fundamental prerequisite for elucidating the driving mechanisms behind successful invasions of invasive alien plants (IAPs). However, a standardized, comprehensive, and operationally feasible methodology for quantifying the relative potential…...