Recently Published Articles

Research Article | Open Access

Published on :   18 Dec 2025

Regenerative Medicine Combined with Physiotherapy in Orthopedic Rehabilitation: Evidence, Mechanisms, and Clinical Protocols

P. Muthukrishnan 1 * S. Rajadurai 2

Regenerative medicine encompasses emerging biologic interventions including platelet-rich plasma (PRP), mesenchymal stem cell (MSC) therapies, and tissue engineering approaches that harness growth factors and cellular biology for musculoskeletal…

Abstract » Full text PDF » Download PDF » doi iconDOI: 10.5281/zenodo.18055250 »

Research Article | Open Access

Published on :   12 Dec 2025

Impact of Oral Contraceptive and Hormone Replacement Therapy Use Resulting in Increased Risk of Meniscal Degeneration in Female Athletes

Amari Eubanks 1 Kiana Allen 1 Dy’Quan Kearney 1 Diwane Mills 1 Damon Ross 1 Madison Burnard 2 Elizabeth Beyene 4 Mekdem Bisrat 4 * Syed Fahad Gillani 3 Miriam Michael 3,4

Background: Meniscus degeneration is the gradual breakdown of cartilage in the knee that could lead to osteoarthritis. Female athletes in high-impact sports are at an increased risk, but the underlying reason for this is unknown.…

Abstract » Full text PDF » Download PDF » doi iconDOI: 10.5281/zenodo.17993710 »

Research Article | Open Access

Published on :   12 Dec 2025

Femur Fracture Risk in HIV-Positive Patients with End Stage Renal Disease: A Comparative Analysis from 2004 2013 to 2014–2023

Keleb Mehari 1 Damon Ross 1 Justin Morrison 1 Ryan Mitchell 1 Rawan Elkomi 1 Syed Fahad Gillani 2 Samrawit Zinabu 2 Mekdem Bisrat 2 * Miriam Michael 2

Background: While femur fractures typically affect the elderly, HIV-positive patients with end stage renal disease (ESRD) are at an accelerated risk due to prolonged antiretroviral therapy (ART) use and bone loss. The combined…

Abstract » Full text PDF » Download PDF » doi iconDOI: 10.5281/zenodo.17993813 »

Research Article | Open Access

Published on :   03 Dec 2025

Intraoperative Ketamine and Postoperative Outcomes After Total Knee Arthroplasty: Association with Revision Surgery and Analgesic Use

Tegshjargal Baasansukh 1 Sarah Gore 1 Chukwudalu Ononenyi 1 Rawan Elkomi 2 Malachi Scott 1 Syed Fahad Gillani 2 Mekdem Bisrat 2 * Miriam Michael 2,3

Background: Ketamine is widely used as an anesthetic adjunct in total knee arthroplasty (TKA), yet its association with surgical revision and postoperative analgesic exposure remains…

Abstract » Full text PDF » Download PDF » doi iconDOI: 10.5281/zenodo.17865918 »

Research Article | Open Access

Published on :   29 Nov 2025

Fracture and Polycystic Ovarian Syndrome in Reproductive-Age Women

Eritrea Negussie 1 Diwane Mills 2 Amari Eubanks 2 Taylor Estes 2 Mekdem Bisrat 2 * Elizabeth Beyene 2 Miriam Michael 2,3

Background: Polycystic ovarian syndrome (PCOS) is a common endocrine disorder in reproductive age women and has been associated with alterations in bone metabolism. However, the clinical impact of PCOS on fracture risk remains…

Abstract » Full text PDF » Download PDF » doi iconDOI: 10.5281/zenodo.17847461 »

Research Article | Open Access

Published on :   28 Nov 2025

Perioperative Tranxemic Acid: A Game-Changer for Hip, Knee, and Spine Surgery Safety

Dy’Quan Kearney 1 Amari Eubanks 1 Syed Fahad Gillani 4 Edward Arenas 1 Elijah McMillian 1 Mekdem Bisrat 2 * Elizabeth Beyene 2 Miriam Michael 2,3

Background: Tranexamic acid (TXA) is widely used in orthopedic surgeries to reduce blood loss, but concerns persist regarding its association with thromboembolic complications. This study aimed to compare the incidence of…

Abstract » Full text PDF » Download PDF » doi iconDOI: 10.5281/zenodo.17844599 »

Case Report | Open Access

Published on :   10 Nov 2025

A Case of Intertrochanteric Valgus Osteotomy for Delayed Presentation of the Paediatric Post-Traumatic Coxa Vara After Neck of Femur Fracture

Dr. Alok Chandra Agrawal 1 Dr. Punit Gaurav 2 * Dr. Harshal S. Sakale 3

Background: Coxa vara in children is a rare but functionally disabling complication following femoral neck fractures, often arising from malunion or growth disturbances. Correction requires addressing both mechanical alignment…

Abstract » Full text PDF » Download PDF » doi iconDOI: 10.5281/zenodo.17655767 »

Review Article | Open Access

Published on :   08 Nov 2025

The Role of Human Leukocyte Antigens in Orthopaedics: Clinical Relevance from Autoimmune Joint Disorders to Implant Compatibility

Dr. Bikram Kesari Kar 1 Dr. Punit Gaurav 2 * Dr. Himanshu 2 Dr. Neeraj Khare 2 Dr. Dushyant Chouhan 3

Background: The human leukocyte antigen (HLA) system is central to immune recognition, orchestrating the distinction between self and non-self-antigens. Its significance in orthopaedics has gained increasing attention due to its…

Abstract » Full text PDF » Download PDF » doi iconDOI: 10.5281/zenodo.17655518 »

Systematic Review | Open Access

Published on :   30 Sep 2025

Type D Personality, Back Pain, and Vagus Nerve Stimulation in Orthopaedic Rehabilitation: A Systematic Narrative Review with Clinical Case

Dr. Christian Riediger 1 * Dr. Mark Ferl 1 Dr. Maria Schönrogge 1 Dr. Agnieszka Halm-Pozniak 1

Background: Type D personality (negative affectivity and social inhibition) is associated with poor outcomes in cardiovascular and orthopaedic populations. Recent studies show significant associations with chronic back pain. Vagus nerve…

Abstract » Full text PDF » Download PDF » doi iconDOI: 10.5281/zenodo.17291125 »

Research Article | Open Access

Published on :   27 Sep 2025

Lumbar Disc Herniation: Etiology and Recovery

Dr. Xinghong Yang 1 *

Lumbar Disc Herniation (LDH) is a common and debilitating condition that often persists or recurs despite conventional medical treatments. It imposes substantial physical, psychological, and social burdens on patients. Modern medicine can offer…

Abstract » Full text PDF » Download PDF » doi iconDOI: 10.5281/zenodo.17291050 »