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Research Article | Open Access

Published on: 20 Dec 2025

Article ID: wjptr.2025.l2001

Effectiveness of an Integrated Multimodal Physiotherapy Rehabilitation Program on Proprioception, Quadriceps Strength, Gait Parameters, Pain, and Functional Outcomes After Total Knee Replacement: A Randomized Controlled Trial
P. Muthukrishnan* 1 S. Rajadurai 2

Background: Post-operative recovery after total knee replacement (TKR) remains challenging, with persistent deficits in proprioception, quadriceps weakness, altered gait mechanics, and chronic pain affecting quality of life in up to 20% of patients.

Objective: To evaluate the effectiveness of an integrated multimodal rehabilitation program combining neuromuscular training, sensorimotor training, functional strengthening, and pain neuroscience…

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Systematic Review | Open Access

Published on: 10 Dec 2025

Article ID: wjptr.2025.l1001

Mechanobiology-Driven Physiotherapy Intervention to Reverse Sarcopenic Cellular Aging: A Randomized Controlled Trial Integrating Myokine Profiling, Mitochondrial Function, and Epigenetic Biomarkers
P. Muthukrishnan* 1 G. Shanmugalakshmi 2

Sarcopenia manifests as age-related skeletal muscle loss accompanied by progressive mitochondrial dysfunction, impaired myokine signaling, and epigenetic aging—yet few randomized controlled trials explore physiotherapy's capacity to reverse these molecular hallmarks. This double-blind parallel RCT evaluated a 12-week mechanobiology-optimized progressive resistance protocol versus stretching control in 80 community-dwelling sarcopenic adults (aged 65-75 years, EWGSOP2 criteria). Primary…

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Research Article | Open Access

Published on: 08 Dec 2025

Article ID: wjptr.2025.l0801

Assessment of the Dynamic Gait Index with and without Cognitive Load in Elderly Non-fallers
Dr. Meghana Mukesh* 1 Dr. S. Nandhakumar 2 Dr. Tittu Thomas James 1

Aims: Most of the rehabilitation assessments concentrate on a unidimensional approach which focuses on challenging and measuring either the executive function (cognitive) components of the task or on its motor components of fallers. This study aimed to assess dynamic balance tasks with and without cognitively load in elderly non-fallers.

Methods: Totally 30 elderly participants with age of 65.57 ± 4.00 were included in the study. Non fallers were…

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Research Article | Open Access

Published on: 06 Dec 2025

Article ID: wjptr.2025.l0601

Post-stroke Depression and Its Relationship with Balance Impairment and Mobility in Patients with Chronic Stroke Hemiparesis – A Correlational Study
Dr. Anamika Sahu* 1 Dr. Ranjeet Singha 2 Dr. Tittu Thomas James 3

Background: Stroke is defined as the immediate loss of neurological function caused by an interruption of the blood supply to the brain or because of the bursting of blood vessels in the brain. A major problem that has been encountered and recorded by clinicians after a stroke attack is depression, which has been found out in almost 33% of patients, and is termed as post-stroke depression (PSD). The balance in gait impairment in stroke patients affects the functional…

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Case Report | Open Access

Published on: 25 Nov 2025

Article ID: wjptr.2025.k2501

Comprehensive Physiotherapy Management in a Patient with Acute Stroke Secondary to Moya Moya Disease: A Case Report
Dr. Rasiqul Ayn 1 Dr. Pradnya Dhargave 2 Dr. Tittu Thomas James* 1

Moya Moya Disease (MMD) is a rare, chronic, and progressive cerebrovascular disorder characterized by the bilateral, stenotic occlusion of the terminal portions of the internal carotid arteries and the proximal parts of the anterior and middle cerebral arteries [1]. This progressive narrowing leads to the formation of a fine, collateral vascular network at the base of the brain, visualized on angiography as a "puff of smoke"—the Japanese term from which the disease derives its name [2]. The…

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