Background & Aims: The long-term risk of colorectal neoplasia in ulcerative colitis (UC) patients undergoing colectomy remains poorly quantified. This study compared the incidence of colorectal malignancies in UC patients with versus without colectomy across 5-year, 10-year, and 20-year follow-up.

Methods: Using the TriNetX US Collaborative Network, we conducted a propensity score-matched cohort study of 3,767 UC patients with colectomy…

Background: Ketamine is widely used as an anesthetic adjunct in total knee arthroplasty (TKA), yet its association with surgical revision and postoperative analgesic exposure remains unclear.

Objectives: To evaluate the association between intraoperative ketamine and one-year revision surgery as well as early postoperative analgesic exposure following primary TKA.

Methods: We conducted a retrospective,…

Ketamine is increasingly being explored as a treatment for depression and has been studied for its potential prophylactic effects in postpartum depression (PPD). This study aims to analyze data from a large population to determine ketamine's efficacy in preventing PPD in patients without a prior history of depression and mitigating symptom escalation in those with a history of depression. Using data from TriNetX, a global health research network, we compare the incidence of PPD among…

An interesting rare case of post-anesthesia spinal epidural hematoma leading to cord compression in an 18-year-old girl having pelvic and bi-lobar hepatic metastatic masses which required operative intervention by laminectomy decompression has been reported. Patient had laparotomy for a pelvic mass with hepatic metastasis for staged debulking and the complication developed on 4th post operative day during mobilization and the anesthesiology, pain control, neurology and surgical teams…

A 45-year-old heterosexual male patient, married with one daughter, with no significant medical history in previous consultations.

He presented to the emergency department at Hospital Arruzafa on 11/08/2022 with whitish discharge, tearing, and discomfort in both eyes. Upon examination, tarsal and bulbar conjunctival hyperaemia, papillary reaction, and mild chemosis were detected.

The initial clinical diagnosis was acute conjunctivitis, likely of viral origin. Appropriate…

Background: Cataract surgery has risen dramatically in the US as a reflection of the growing geriatric population. Despite its safety and efficacy, elderly patients remain vulnerable to postoperative cognitive dysfunction (POCD). Previous studies have shown ketamine and dexmedetomidine to have neuroprotective effects. This study aims to examine its association with POCD using the TriNetX database, mirroring a prior randomized trial and assessing outcomes at 1 week, 3 months,…

Background: Charcot-Marie-Tooth disease (CMT) is a genetically heterogeneous peripheral neuropathy traditionally considered to spare the central nervous system (CNS). However, recent reports suggest possible CNS involvement, including cognitive impairment and sleep disturbances. The true prevalence of these manifestations remains unclear due to limited large-scale data.

Methods: We conducted a retrospective cohort study using data from 141…

Prostate cancer is the second most common malignancy and the leading cause of cancer death in men across Sub-Saharan Africa (SSA). Despite lower reported incidence rates compared to African American men, actual prostate cancer prevalence in SSA is under-reported and likely underestimated due to inadequate screening and limited access to healthcare. This study analyzed registry data from 13,170 prostate cancer cases across 11 SSA countries to evaluate trends in incidence rates over time.…

Background: Polycystic ovarian syndrome (PCOS) is a common endocrine disorder in reproductive age women and has been associated with alterations in bone metabolism. However, the clinical impact of PCOS on fracture risk remains unclear, particularly in patients with coexisting uterinefibroids.

Methods: We conducted a retrospective cohort study using the Global Collaborative Network database. Women aged 15–45 with both PCOS and uterine fibroids…

Background: Lumbosacral radiculopathy (sciatica) commonly arises from lumbar disc herniation and presents with radiating leg pain, paresthesia, and functional disability. Neurodynamic tests such as the Straight Leg Raise (SLR) and Slump tests are routinely used to evaluate neural mechanosensitivity; however, quantitative comparisons between symptomatic and asymptomatic individuals remain limited.

Objective: To quantify and compare lower limb…