Bone fractures represent a major global health concern and are most commonly attributed to trauma, osteoporosis, metabolic disorders, or age-related degeneration. The majority of fractures heal through well-characterized biological processes, and preventive strategies typically emphasize enhancing bone strength, improving balance, and ensuring environmental safety. However, a subset of individuals experiences frequent and recurrent fractures over extended periods despite adequate nutrition…

A 52‑year‑old woman developed a febrile diarrhoeal illness during a pilgrimage in India, requiring intravenous ceftriaxone. She later experienced persistent dry cough and mediastinal lymphadenitis. Two months after returning to the UK, she developed sudden severe thoracic pain with systemic symptoms. Early investigations and non‑contrast MRI were non‑diagnostic. A focused contrast‑enhanced MRI revealed destructive T8–T9 discitis. CT‑guided biopsy confirmed Salmonella typhi. This case…

Mesenchymal Hamartoma of the Liver (MHL) is a rare benign hepatic pediatric tumor of infancy with approximately 20% of cases diagnosed during the neonatal period, typically presenting as an enlarging abdominal mass. Rare acute complications such as intralesional bleeding and infection can lead to rapid clinical deterioration. Neonatal presentation with infection, haemorrhage, and extension along the falciform ligament is exceptionally uncommon. We report a neonate who presented with sepsis…

Editorial While the opt‑out model represents an important policy shift, evidence shows that legislation alone cannot deliver the cultural and behavioural change required to increase donation rates. T he editorial argues that meaningful progress depends on strengthening public understanding, normalising family conversations, supporting clinicians in sensitive communication, and building trust through transparency and community engagement. By reframing organ donation as an…

To synthesise current evidence on professional burnout among physicians, with a focus on epidemiology, causes, clinical manifestations, diagnostic approaches, prevention strategies, and management. The review also examines the role of work–life balance as a modifiable determinant of burnout risk.

Design: Narrative review.

Methods: A targeted literature search was conducted using MEDLINE, Embase, PsycINFO, and grey literature sources.…

Objectives: To synthesise current evidence on Bowel motility and Bladder Disorders (BBD) and menstrual disorders across early childhood through adolescence, highlighting shared pathophysiology, psychosocial determinants, and opportunities for integrated, holistic management. T he review emphasises developmental transitions, family context, and system‑level approaches relevant to paediatric and adolescent care.

Design: Narrative review of…

In today’s world, herbal or “natural” insecticides are generally considered benign, but their toxic potential remains inadequately recognized. We report the case of a 75-year-old man who voluntarily took a commercially available herbicide containing terpenes, alkaloids, lactones and emulsifiers. He presented himself to the emergency department with repeated vomiting, altered sensors, progressive cyanosis and hypoxia, which did not improve despite additional oxygen. Initial clinical results…

Introduction: Primary Hyperparathyroidism (PHPT) is frequently associated with vitamin D deficiency, which may exacerbate hyperparathyroidism, hypercalcemia, and bone complications.

Objective: To assess vitamin D status in patients with PHPT and analyze its biological and clinical impact.

Patients and Methods: A retrospective study conducted over seven years (2015-2022) including patients hospitalized for PHPT. Serum…

Introduction: Multiple Endocrine Neoplasia type 2A (MEN2A) is a rare genetic disorder primarily characterized by Medullary Thyroid Carcinoma (MTC) and Primary Hyperparathyroidism (PHPT) in 20 to 30% of cases. PHPT is rarely the initial presenting symptom. This study aims to describe the clinical and biological features of PHPT in MEN2A to improve understanding and management of this condition.

Patients and Methods: This is a retrospective…

Ectopic mediastinal parathyroid adenoma is a significant cause of refractory and recurrent primary hyperparathyroidism. Although rare compared to cervical locations, this pathology presents particular diagnostic and therapeutic challenges. We report a series of three cases illustrating these difficulties, along with favorable outcomes achieved through advanced imaging and appropriate surgical management. An updated literature review is provided to better understand the optimal care for these…