WebLog Journal of Neurology

We describe a mother–infant dyad. The mother, a 16‑year‑old teenager, presented with a background of lifelong chronic constipation, recurrent abdominal discomforts, pain and distension, and malabsorption. The patient presented suddenly with progressive gait disturbance, and profound anemia. She was diagnosed with hypoganglionosis on full‑thickness biopsy and SCD on MRI. Her infant daughter presented at 7 months with acute ileocolic intussusception, requiring radiological reduction. Both…

Drug-induced parkinsonism (DIP) is a debilitating side effect associated with several classes of medications. Amlodipine is a widely used dihydropyridine calcium channel blocker (CCB) commonly prescribed for hypertension and angina. We present a case of a 62-year-old man who underwent liver transplantation and developed parkinsonism shortly after initiation of amlodipine for hypertension. After ruling out other causes for his neurological presentation, discontinuation of amlodipine resulted…

Neurological physiotherapy is entering a pivotal phase where conventional protocol-driven care is increasingly misaligned with the complexity and heterogeneity of real-world disability. Patients with stroke, traumatic brain injury, spinal cord injury, Parkinsonian syndromes, and other central nervous system disorders present with highly individualized movement impairments that evolve over time. Yet most rehabilitation pathways remain anchored to coarse clinical scales and therapist…

Background: Charcot-Marie-Tooth disease (CMT) is a genetically heterogeneous peripheral neuropathy traditionally considered to spare the central nervous system (CNS). However, recent reports suggest possible CNS involvement, including cognitive impairment and sleep disturbances. The true prevalence of these manifestations remains unclear due to limited large-scale data.

Methods: We conducted a retrospective cohort study using data from 141…

Background: Lumbosacral radiculopathy (sciatica) commonly arises from lumbar disc herniation and presents with radiating leg pain, paresthesia, and functional disability. Neurodynamic tests such as the Straight Leg Raise (SLR) and Slump tests are routinely used to evaluate neural mechanosensitivity; however, quantitative comparisons between symptomatic and asymptomatic individuals remain limited.

Objective: To quantify and compare lower limb…

Bathing-related reflex epilepsy (BRE) is an uncommon type of reflex epilepsy characterized by seizures that are reliably induced by contact with water during bathing or showering. In contrast to the more prevalent hot-water epilepsy (HWE), which is temperature-dependent, typically focal, and often benign, bathing-related epilepsy (BRE) can manifest with water of any temperature, display generalized features, and demonstrate resistance to pharmacological treatment. A 22-year old male is…