WebLog Journal of Endocrinology and Diabetes

Double diabetes refers to the coexistence, in the same patient, of immunological features of type 1 diabetes (T1D) and clinical and metabolic manifestations of type 2 diabetes (T2D), especially insulin resistance. This entity, still insufficiently recognized, poses diagnostic and therapeutic challenges, particularly in adults. We report a series of three cases of double diabetes in adult female patients, illustrating the clinical heterogeneity of this condition, and discuss the…

Introduction: Von Hippel–Lindau (VHL) disease is an autosomal dominant genetic disorder predisposing to the development of benign and malignant tumors, notably pheochromocytomas, which are often bilateral and of early onset.

Objective: To describe the clinical, biological, radiological, and evolutionary characteristics of patients with bilateral pheochromocytomas associated with VHL disease and to compare our results with the literature…

Introduction: Testicular regression syndrome (TRS) is a rare cause of disorders of sex development in 46,XY individuals. It corresponds to the partial or complete disappearance of testicular tissue following initially normal male differentiation.

Objective: To describe the clinical, biological, radiological, and evolutionary characteristics of a series of 7 patients followed for TRS, and to compare them with recent literature…

Introduction: Rathke’s cleft cyst (RCC) is a rare benign cystic lesion of the sellar region arising from an embryonic remnant of Rathke’s pouch. Although often asymptomatic, it may become responsible for endocrine, neurological, or ophthalmological manifestations when it is large or compressive.

Objective: To describe the clinical, hormonal, radiological, therapeutic, and evolutionary characteristics of symptomatic Rathke’s cleft cysts through a…

Introduction: Cushing’s syndrome (CS) during pregnancy is a rare and complex condition due to the overlap of symptoms with normal physiological changes during pregnancy and the associated maternal and fetal risks.

Objective: To describe three cases of Cushing’s syndrome diagnosed during or shortly after pregnancy, detailing clinical characteristics, diagnostics, management, and outcomes, alongside a review of recent…

Introduction: Oculomotor palsies are a rare manifestation of focal diabetic neuropathies. Their clinical presentation may mimic serious neurological conditions, making diagnosis challenging. Objective: To report a series of four cases of oculomotor palsy in diabetic patients and to analyze their clinical, diagnostic, therapeutic, and evolutionary characteristics in light of the literature.

Patients and Methods: A retrospective descriptive study…

Introduction: The association between type 1 diabetes (T1D) and epilepsy has been reported more frequently than in the general population. However, the exact pathophysiological link remains poorly understood.

Objective: To describe the clinical characteristics of patients presenting with an association of T1D and epilepsy and to discuss the possible pathophysiological mechanisms in light of data from the…

Introduction: Primary hyperparathyroidism (PHPT) is one of the most common endocrine disorders, characterized by inappropriate secretion of parathyroid hormone (PTH), leading to disturbances in calcium–phosphate metabolism and multisystem complications.

Objective: To determine the prevalence and profile of clinical, biological, and radiological complications of PHPT in a Moroccan hospital-based cohort.

Materials and…

Introduction: Celiac disease (CD) is an autoimmune enteropathy triggered by gluten ingestion in genetically predisposed individuals. It is frequently associated with type 1 diabetes (T1D), with a prevalence significantly higher than that observed in the general population. Diagnosis usually relies on positivity of specific autoantibodies and histological confirmation. However, seronegative forms can be observed, notably in T1D patients, making diagnosis more…

Introduction: Graves’ disease is an autoimmune disorder characterized by hyperthyroidism related to the presence of thyroid-stimulating hormone receptor antibodies. Long considered protective against thyroid cancer, it is now recognized as potentially associated with differentiated thyroid carcinomas, mainly papillary carcinoma.

Objective: To describe the clinical, histological, therapeutic, and outcome characteristics of thyroid carcinomas…