WebLog Journal of Endocrinology and Diabetes

Non-Classical Congenital Adrenal Hyperplasia (NCCAH) due to partial 21-hydroxylase deficiency is a frequent and often underdiagnosed cause of hyperandrogenism in women. We report the case of a 39-year-old woman presenting with severe hirsutism. Hormonal evaluation revealed elevated 17-Hydroxyprogesterone (17OHP), confirmed after ACTH stimulation, consistent with NCCAH. Imaging findings were normal. This case highlights the importance of systematic screening for this condition in the…

Ectopic parathyroid adenomas are rare and usually present with biochemical hyperparathyroidism. They most frequently occur in the mediastinum or thymic region. Localization within a lymph node along the recurrent laryngeal nerve chain is extremely rare. We report a case of a 70-year-old woman in whom a non-functioning ectopic parathyroid adenoma was incidentally discovered within a lymph node of the right recurrent laryngeal nerve chain during surgery for a suspicious thyroid nodule.…

Graves’ disease is an autoimmune disorder characterized by the presence of stimulating antibodies directed against the thyroid-stimulating hormone (TSH) receptor, leading to hyperthyroidism. It may occur in an autoimmune background and can be associated with other systemic autoimmune diseases such as rheumatoid arthritis, systemic lupus erythematosus, or Sjögren’s syndrome. Hepatic involvement during hyperthyroidism is well described and may be related either to the disease itself or to…

Introduction: Familial non-medullary thyroid carcinoma accounts for 3-7% of differentiated thyroid cancers. It is defined by the occurrence of papillary thyroid carcinoma in at least two first degree relatives in the absence of a known hereditary syndrome.

Case Presentation: We report the case of a 56-year-old mother and her 35-year-old daughter, both diagnosed with papillary thyroid carcinoma discovered in EU-TIRADS V classified nodules.…

Introduction: Dyshormonogenetic goiter is a rare cause of congenital hypothyroidism secondary to a defect in thyroid hormonogenesis. Despite early replacement therapy, a compressive multinodular goiter may appear in adulthood.

Observations: We report two patients aged 19 and 28 years, followed since childhood for congenital hypothyroidism, who developed a compressive multinodular goiter treated by total thyroidectomy. Histopathological…

Behçet's disease (BD) is a systemic vasculitis widely prevalent in countries along the ancient Silk Road and around the Mediterranean. Endocrine complications are uncommon in this vasculitis. Non-corticosteroid-induced diabetes mellitus remains exceptional in BD. We report three cases of BD associated with diabetes mellitus type 2 in three Tunisian patients. They are two women and a man aged 42, 37, and 48 years old respectively with mean body mass index at 22.33 kg/m². Diabetes occurred at…

Recurrent miscarriages are a rare occurrence in routine medical practice (1-3% of pregnancies) and represent a significant diagnostic challenge.

Subclinical hypothyroidism (SCH) is the most common thyroid disorder during pregnancy (3-5% of pregnant women) and can be responsible for several obstetric complications such as miscarriage, preterm birth, gestational hypertension, preeclampsia, and increased perinatal mortality. SCH remains an exceptional and still controversial cause…

Introduction: Primary Hyperparathyroidism (PHPT) is frequently associated with vitamin D deficiency, which may exacerbate hyperparathyroidism, hypercalcemia, and bone complications.

Objective: To assess vitamin D status in patients with PHPT and analyze its biological and clinical impact.

Patients and Methods: A retrospective study conducted over seven years (2015-2022) including patients hospitalized for PHPT. Serum…

Introduction: Multiple Endocrine Neoplasia type 2A (MEN2A) is a rare genetic disorder primarily characterized by Medullary Thyroid Carcinoma (MTC) and Primary Hyperparathyroidism (PHPT) in 20 to 30% of cases. PHPT is rarely the initial presenting symptom. This study aims to describe the clinical and biological features of PHPT in MEN2A to improve understanding and management of this condition.

Patients and Methods: This is a retrospective…

Ectopic mediastinal parathyroid adenoma is a significant cause of refractory and recurrent primary hyperparathyroidism. Although rare compared to cervical locations, this pathology presents particular diagnostic and therapeutic challenges. We report a series of three cases illustrating these difficulties, along with favorable outcomes achieved through advanced imaging and appropriate surgical management. An updated literature review is provided to better understand the optimal care for these…