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Published on :   15 Dec 2025

Cytomegalovirus Anterior Uveitis Masquerading as Ocular Tuberculosis: A Diagnostic Challenge in an Immigrant Patient with Latent Tuberculosis

Luke M. Nelson 1 Kira Yates 1 Armando Ugarte 1 Katrina Chin Loy 1 Miriam Michael 2 Brian K. Do 3,4 Siham Mahgoub 5 *

Purpose: To describe a case of cytomegalovirus (CMV) anterior uveitis misdiagnosed as presumed ocular tuberculosis (TB) in an immunocompetent immigrant patient, leading to delayed diagnosis, corneal graft failure, and eventual vision loss.

Observations: A 74-year-old Filipino male with recurrent unilateral hypertensive anterior uveitis and a positive QuantiFERON-TB Gold test was treated for presumed ocular TB with RIPE therapy. Despite treatment,…

Abstract » Full text PDF » Download PDF » doi iconDOI: 10.5281/zenodo.18027481 »

Published on :   13 Dec 2025

Primary Hyperparathyroidism Revealed by a Brown Tumor: A Series of 9 Cases

Gorgi K 1 * Chaouche M 2

Brown tumors are bone manifestations of hyperparathyroidism (HPT). They usually occur in severe forms accompanied by signs of periosteal bone resorption. Their treatment mainly relies on parathyroidectomy.

We report a series of 9 cases of primary hyperparathyroidism revealed by a brown tumor. These clinical cases highlight the importance of phosphocalcic assessment in the presence of any bone swelling suggestive of a brown tumor.

Keywords: Brown Tumor;

Abstract » Full text PDF » Download PDF » doi iconDOI: 10.5281/zenodo.18000001 »

Published on :   13 Dec 2025

Oncocytic Carcinoma: A Series of 5 Cases

Gorgi K 1 * Chaouche M 2

Oncocytic thyroid carcinoma is a rare tumor characterized by the proliferation of Hürthle (oncocytic) cells. It is an aggressive tumor and is insensitive to radioiodine therapy. We report a series of five patients diagnosed with oncocytic carcinoma.

Keywords: Oncocytic Carcinoma; Hürthle Cell Tumor; Total Thyroidectomy; Radioiodine Therapy

Abstract » Full text PDF » Download PDF » doi iconDOI: 10.5281/zenodo.18000188 »

Published on :   13 Dec 2025

Diabetic Ketoacidosis and Thromboembolic Disease in Type 1 Diabetes: A Series of 5 Cases

Gorgi K 1 * Chaouche M 2

Diabetic ketoacidosis (DKA) is a frequent complication that generally evolves favorably; however, thromboembolic complications may occur. Pulmonary embolism is a rare complication. We report a series of five cases of type 1 diabetic female patients presenting with DKA complicated by thromboembolic disease, along with a review of the literature.

Keywords: Thrombosis; Hypercoagulability; Prophylactic Anticoagulation; Pulmonary Embolism

Abstract » Full text PDF » Download PDF » doi iconDOI: 10.5281/zenodo.18000326 »

Systematic Review | Open Access

Published on :   13 Dec 2025

Umbilical Anomalies and Exomphalos: A Review of Current Practice

Zaparackaite I 1 Govani ND 2 Singh H 3 Singh SJ 4 Mehta AR 5 Midha PK 5 Patel R 2 Patel RV 2 *

Objective: To review current practice in the diagnosis and management of umbilical anomalies, with emphasis on exomphalos.

Design: Narrative review of published literature and clinical guidelines.

Results: Umbilical anomalies range from minor hernia of the cord to giant exomphalos. Antenatal diagnosis is feasible with ultrasound and MRI. Management strategies vary from primary closure to staged silo reduction and…

Abstract » Full text PDF » Download PDF » doi iconDOI: 10.5281/zenodo.18001331 »

Research Article | Open Access

Published on :   12 Dec 2025

Impact of Oral Contraceptive and Hormone Replacement Therapy Use Resulting in Increased Risk of Meniscal Degeneration in Female Athletes

Amari Eubanks 1 Kiana Allen 1 Dy’Quan Kearney 1 Diwane Mills 1 Damon Ross 1 Madison Burnard 2 Elizabeth Beyene 4 Mekdem Bisrat 4 * Syed Fahad Gillani 3 Miriam Michael 3,4

Background: Meniscus degeneration is the gradual breakdown of cartilage in the knee that could lead to osteoarthritis. Female athletes in high-impact sports are at an increased risk, but the underlying reason for this is unknown. The deficiency of sex hormones (i.e, Estrogen) is known to influence connective tissue and joint health. Still, the impact of elevated hormones, such as those from oral contraceptives and hormone replacement therapy, is unknown. The study aims to…

Abstract » Full text PDF » Download PDF » doi iconDOI: 10.5281/zenodo.17993710 »

Research Article | Open Access

Published on :   12 Dec 2025

Femur Fracture Risk in HIV-Positive Patients with End Stage Renal Disease: A Comparative Analysis from 2004 2013 to 2014–2023

Keleb Mehari 1 Damon Ross 1 Justin Morrison 1 Ryan Mitchell 1 Rawan Elkomi 1 Syed Fahad Gillani 2 Samrawit Zinabu 2 Mekdem Bisrat 2 * Miriam Michael 2

Background: While femur fractures typically affect the elderly, HIV-positive patients with end stage renal disease (ESRD) are at an accelerated risk due to prolonged antiretroviral therapy (ART) use and bone loss. The combined impact of these factors on fracture trends remains under-explored.

Objective: To evaluate the association between femur fractures and the coexistence of HIV and ESRD, and to analyze trends in fracture incidence and…

Abstract » Full text PDF » Download PDF » doi iconDOI: 10.5281/zenodo.17993813 »

Published on :   10 Dec 2025

Mechanobiology-Driven Physiotherapy Intervention to Reverse Sarcopenic Cellular Aging: A Randomized Controlled Trial Integrating Myokine Profiling, Mitochondrial Function, and Epigenetic Biomarkers

P. Muthukrishnan 1 * G. Shanmugalakshmi 2

Sarcopenia manifests as age-related skeletal muscle loss accompanied by progressive mitochondrial dysfunction, impaired myokine signaling, and epigenetic aging—yet few randomized controlled trials explore physiotherapy's capacity to reverse these molecular hallmarks. This double-blind parallel RCT evaluated a 12-week mechanobiology-optimized progressive resistance protocol versus stretching control in 80 community-dwelling sarcopenic adults (aged 65-75 years, EWGSOP2 criteria). Primary…

Abstract » Full text PDF » Download PDF » doi iconDOI: 10.5281/zenodo.17993518 »

Review Article | Open Access

Published on :   10 Dec 2025

Understanding Etiopathogenesis, Pathophysiology, Diagnosis and Innovative Approaches to Management of Infantile Colic: A Narrative Review of the Literature and Multi-center Experience

Zaparackaite I 1 Govani ND 2 Singh H 3 Singh SJ 4 Mehta AR 5 Midha PK 5 Patel R 2 Patel RV 2 *

Objective: Infantile colic is a common functional gastrointestinal disorder characterized by excessive crying in otherwise healthy infants. This review synthesizes current evidence on epidemiology, etiopathogenesis, pathophysiology, diagnostic criteria, and management strategies in the light of our multicentre international evidence based long term experience.

Design: Narrative review of published systematic reviews, meta-analyses, and guidelines…

Abstract » Full text PDF » Download PDF » doi iconDOI: 10.5281/zenodo.17993618 »

Published on :   08 Dec 2025

Assessment of the Dynamic Gait Index with and without Cognitive Load in Elderly Non-fallers

Dr. Meghana Mukesh 1 * Dr. S. Nandhakumar 2 Dr. Tittu Thomas James 1

Aims: Most of the rehabilitation assessments concentrate on a unidimensional approach which focuses on challenging and measuring either the executive function (cognitive) components of the task or on its motor components of fallers. This study aimed to assess dynamic balance tasks with and without cognitively load in elderly non-fallers.

Methods: Totally 30 elderly participants with age of 65.57 ± 4.00 were included in the study. Non fallers were…

Abstract » Full text PDF » Download PDF » doi iconDOI: 10.5281/zenodo.17874737 »