Background: One of the frequent problems after gynaecological surgery is postoperative pain which can have a significant impact on the patient's recovery, hospital stay and overall satisfaction. The use of minimally invasive gynaecological procedures such as Laparoscopic Surgery is growing in popularity as they have a smaller incision, less tissue trauma and quicker recovery time when compared to traditional open surgery. But there are clinically significant differences…

The global health burden of Type 2 Diabetes Mellitus (T2DM) is growing, with over 537 million adults estimated to be affected, rising to 783 million by 2045. Growing evidence shows that gut microbiome dysfunction plays an important role in the development of T2DM. Microbiome dysbiosis contributes to insulin resistance by multiple overlapping mechanisms and presumes the disruption of intestinal barrier functions (e.g., by endotoxins generated by Lipopolysaccharides [LPS]) and the depletion of…

Medicinal plants constitute a major renewable source of bioactive secondary metabolites that underpin traditional and modern pharmaceutical industries, yet their supply from wild and field-cultivated sources is increasingly constrained by slow growth rates, seasonal and geographic variability, over harvesting, and inconsistent phytochemical yield. Biostimulants - including seaweed extracts, humic substances, protein hydrolysates, and Plant Growth-Promoting Rhizobacteria (PGPR) - and Plant…

The first theoretical investigation on NiF2 /picolinic acid-catalyzed chemoselective cou-pling− cyclization of 2-iodobenzamide and malonate was provided by our DFT calculation. First in Ni(I)/ Ni(III) catalytic cycle, NiF2 and PicA are converted to L2 Ni(II) complex together with leaving of first HF molecule. Then malonate anion is generated from dimethyl malonate after removal of second HF molecule. The deprotona-tion of malonate gives enolate as single-electron reductant furnishing Ni(I)…

The first theoretical investigation on DABCO-mediated aza-Michael reaction of sulfonyli minoindoline and α,β-unsaturated aldehyde was provided by our DFT calculation. First, 2-aminotosyl indole is given in equilibrium with 2-sulfonamidoindoline via deprotonation with the help of DABCO. Then, it undergoes aza-Michael reaction with α,β-unsaturated aldehyde to form transient carbanion. The ring closure occurs leading to four-membered transient 1,2-thiazetidine, from which the sulfonyl moiety is…

The first theoretical investigation on TMSOTf-promoted cascade reaction of propargyl alcohol and protected tryptamine was provided by our DFT calculation. First, propargyl alcohol is activated by TMSOTf resulting in silyl ether accompanied by release of triflic acid. Then silyl ether undergoes Meyer-Schuster re-arrangement generating allenic intermediate and HOSiMe3. Hydroxyl is transferred from the latter to ter-minal alkyne carbon along with recovered TMSOTf. Subsequently, the…

Cancer remains a major global health challenge, necessitating the development of novel and safe therapeutic agents. Medicinal plants are recognized as valuable sources of bioactive molecules with anticancer potential. Cecropia pachystachya Trécul (Urticaceae), a species traditionally used in South American medicine, has recently garnered attention for its cytotoxic and antitumor properties. This review highlights cancer-related findings published primarily over the last five years, focusing…

Background: Chronic lower extremity lymphedema is a progressive condition characterized by persistent swelling, discomfort, heaviness, impaired mobility, and functional limitations. These symptoms may substantially affect balance, gait, physical activity, and quality of life. Although exercise is increasingly recognized as an important component of lymphedema management, evidence regarding the use of individualized Clinical Pilates in patients with chronic lower extremity…

Tropical Cyclones (TCs) in the Australian basin have relatively more erratic pathways than other parts of the world. About half the TCs generated in the basin make landfall, but the location of cyclogenesis appears to have a direct bearing on landfall outcome. As the human and economic toll of landfalling TCs are far more significant than the non-landfalling ones, this paper attempts to identify the distinguishing features that differentiate between the two and, develops a decision tree…

Background: Personal electronic health devices, such as fitness trackers, heart rate monitors, blood glucose meters, blood pressure monitors and stress level meters, and related smartphone based health applications are increasing in usage and popularity. These Internet-based medical technologies, which this paper refers to as mHealth systems, may be prescribed by a healthcare professional or purchased over-the-counter and make it easier for an individual to collect, access…