Nelson’s syndrome is a severe complication that may develop in patients with Cushing’s disease treated with bilateral adrenalectomy. Since pituitary tumors in Nelson’s syndrome are often aggressive, early diagnosis and careful management are essential. We report three cases illustrating this syndrome.

Keywords: Nelson’s Syndrome; Pituitary Adenoma; Corticotroph Tumor; Adrenocorticotropic Hormone (ACTH); Bilateral Adrenalectomy; Cushing’s Disease;…

Sertraline, a selective serotonin reuptake inhibitor (SSRI), has been associated with rare cases of acute pancreatitis. We report a case of sertraline-induced, lipase-sparing acute interstitial edematous pancreatitis in a young professional, initially misdiagnosed as acute cholecystitis. On rechallenge, the patient developed recurrent symptoms with elevated inflammatory markers but normal ultrasound findings. Contrast-enhanced computed tomography confirmed acute interstitial edematous…

Objective: To review the emerging concept of the oral–gut axis and highlight the role of hygiene practices—including oral, perianal, perineal, hand, environmental, and food hygiene—in maintaining gut health and preventing systemic disease.

Design: Narrative review of peer‑reviewed literature from 2000–2025.

Results: Oral and gut microbiomes are interconnected through shared microbial pathways and immune signaling.…

Infantile colic is a common functional gastrointestinal disorder characterized by excessive crying in otherwise healthy infants, Infantile colic is a common, self-limiting condition. Pharmacological interventions, particularly anticholinergic agents, have historically been attempted and used but are associated with significant risks and not recommended due to safety concerns. We report a 6-week old female infant who developed acute colonic pseudo-obstruction following administration of…

Background: Post-operative recovery after total knee replacement (TKR) remains challenging, with persistent deficits in proprioception, quadriceps weakness, altered gait mechanics, and chronic pain affecting quality of life in up to 20% of patients.

Objective: To evaluate the effectiveness of an integrated multimodal rehabilitation program combining neuromuscular training, sensorimotor training, functional strengthening, and pain neuroscience…

This study evaluates the environmental impact of private and business aviation, with a focus on emissions generated by specific aircraft operating in Poland in 2024. Three aircraft models—Pilatus PC-12, Bombardier Challenger 350, and Dassault Falcon 900EX—were analyzed in terms of flight frequency, fuel consumption, and emissions of CO₂, CO, NOx , CHx, and soot. Data were collected daily over one year, covering 419 flights, allowing for precise mapping of route networks and operational…

Regenerative medicine encompasses emerging biologic interventions including platelet-rich plasma (PRP), mesenchymal stem cell (MSC) therapies, and tissue engineering approaches that harness growth factors and cellular biology for musculoskeletal repair. While individually effective, recent evidence demonstrates that combining regenerative therapies with evidence-based physiotherapy protocols produces superior functional outcomes, sustained pain relief, and structural tissue regeneration…

Neurological physiotherapy is entering a pivotal phase where conventional protocol-driven care is increasingly misaligned with the complexity and heterogeneity of real-world disability. Patients with stroke, traumatic brain injury, spinal cord injury, Parkinsonian syndromes, and other central nervous system disorders present with highly individualized movement impairments that evolve over time. Yet most rehabilitation pathways remain anchored to coarse clinical scales and therapist…

Smartphone usage has become ubiquitous globally, yet prolonged screen time contributes to significant postural abnormalities including forward head posture and rounded shoulders in regular users. The current study builds upon previous pilot investigations examining the efficacy of targeted stretching and strengthening protocols in correcting these postural deviations. This evidence based review synthesizes findings from recent clinical trials examining interventions designed to ameliorate…

Previously, we reported that the von Hippel-Lindau (VHL) tumor suppressor gene induces neural stem cell (NSC) differentiation to neurons, and that VHL's involvement in differentiating NSCs or mesenchymal stem cells (MSCs) into neurons is related to the inhibition of the JAK/STAT pathway through the proteasomal degradation of proteins following their ubiquitination by the VHL/ elonginBC/Cul2 complex. However, the relationship between VHL and other pathways and factors around VHL-mediated…