Nipple stimulation, particularly through oral contact, has long been recognized as a significant component of human sexual behavior, yet scholarly attention to its role in male sexual response remains limited. While existing research predominantly focuses on the physiological and psychological effects of nipple stimulation in women, comparatively little is known about its implications for men during intimate encounters. This paper explores the perceived pleasure and psychological…

Human breast milk is a unique bio-fluid rich in nutrients and bioactive molecules, including proteins with potential therapeutic applications. Among these, the α-lactalbumin–oleic acid complex, known as HAMLET (Human Alpha-lactalbumin Made Lethal to Tumor cells), has been reported to selectively induce apoptosis in tumor cells while sparing normal cells. While previous studies have primarily focused on Western populations, limited research has investigated the anti-cancer properties of…

Translational medicine areas include areas aimed at applying the results of basic research to develop new methods for diagnosing, treating and preventing diseases. The main areas of translational medicine are, firstly, personalized medicine - development of individual approaches to treatment based on the patient’s genetic, molecular and clinical information. Secondly, molecular diagnostics - creation of methods for identifying biomarkers and genetic markers of diseases for early diagnosis…

Psoriasis is a chronic and burdensome skin disease that affects millions worldwide, and current biomedical research has uncovered complex genetic, immune, and environmental interactions underlying its pathology. These advances have improved symptom management through biologics and other therapies, but a true cure remains elusive, as treatments only suppress symptoms without addressing the root cause. Therefore, this study introduces the Buddhist perspective of Guan Yin Citta Dharma Door,…

Enzymes are crucial biological catalysts that facilitate a wide array of biochemical reactions essential for life. The evolution and diversity of enzyme systems across species are central to understanding organismal adaptation and survival in varied environmental conditions. This paper explores the evolutionary mechanisms that drive the diversity of enzymes across different species, focusing on key enzyme families, metabolic pathways, and the role of genetic and environmental factors. By…

Sexual enzymes play a crucial role in regulating female reproductive and sexual health. These enzymes, including aromatase, phosphodiesterase type 5 (PDE5), hyaluronidase, lipoprotein lipase, and matrix metalloproteinases, are involved in various physiological processes that affect sexual arousal, lubrication, and tissue remodeling. Aromatase, for instance, regulates the conversion of androgens to estrogens, influencing libido and reproductive cycles. PDE5, while traditionally associated…

Our DFT calculation provided the first theoretical investigation on Lewis/Brønsted acids-catalyzed syntheses of bicyclo[2.1.1]hexane and spirocyclic compound from disubstituted BCB and ester activated quinone. For [2π + 2σ] cycloaddition with Ni(OTf)2 , BCB was activated as nucleophile to attack quinone initially. Then bicyclic product was achieved via cyclization. For (3 + 2) cycloaddition with DTBP, the dehydrogenation of BCB and aromatization of quinone is promoted owing to enhanced…

Infectious disease pose a significant worldwide fitness burden, exacerbated by the increasing prevalence of antimicrobial opposition (AMR). Traditional cures have utilized plant-derived compounds for a certain time, contributing to a promising alternative to artificial antimicrobials. This review surveys the role of plant-derivative antimicrobials in catching disease administration and emphasizes their mechanisms of operation, healing applications, and challenges. Key machines contain…

Individuals' motivation to commit crime is often influenced by a confluence of factors such as mental health, emotional needs, economic status, social environment and family background. In addition, social factors such as social inequality, poverty, unemployment and social exclusion also play an important role in the formation of criminal motivation. An in-depth study of offenders' motivation can not only reveal the root causes of criminal behavior, but also provide a theoretical basis for…

Attention-Deficit/Hyperactivity Disorder (ADHD) is a common neurodevelopmental disorder that affects children and can persist into adulthood, posing significant challenges in academic, social, and family settings. Pharmacological treatment remains one of the most widely used and effective approaches. In addition to medication, behavioral therapy has been proven effective in improving behavior and emotional regulation, and is often combined with medication for a more comprehensive treatment.…