Gorgi K ^{1 *} Chaouche M ²

Primary hyperparathyroidism (PHPT) is a common endocrine disorder characterized by inappropriate parathyroid hormone (PTH) secretion leading to chronic hypercalcemia. Acute pancreatitis is a rare but potentially severe complication of PHPT. We report three cases in which acute pancreatitis was the revealing manifestation of primary hyperparathyroidism. These observations emphasize the importance of systematically investigating metabolic causes, particularly hypercalcemia, in cases of acute…

N. Krishna Prakash ^{1 *} P. Muthukrishnan ²

Background: Knee osteoarthritis (KOA) in geriatric populations presents a multifaceted challenge characterized by progressive cartilage degradation, sensorimotor dysfunction, and compromised joint stability. While pain management remains central to rehabilitation, proprioceptive dysfunction and impaired dynamic stability represent significant but understudied mechanisms in older adults with KOA. This randomized controlled trial investigates the efficacy of structured…

N. Krishna Prakash ^{1 *} P. Muthukrishnan ²

Background: Knee osteoarthritis (KOA) significantly impairs functional capacity and independence in geriatric populations, with increased susceptibility to falls and reduced quality of life. While both neuromuscular re-education (NMR) and conventional strengthening (CS) have demonstrated efficacy, comparative evidence remains limited.

Objective: This randomized controlled trial (RCT) compared the effectiveness of neuromuscular re-education versus…

K. Gorgi ^{1 *} M. Chaouche ² K. Rifai ¹ H. Iraqi ¹ M.H. Gharbi ¹

The synchronous occurrence of laryngeal squamous cell carcinoma (LSCC) and papillary thyroid carcinoma (PTC) is rare and is most often discovered incidentally on histopathological examination of surgical specimens. We report a series of four cases illustrating this uncommon association, focusing on clinical presentation, histological findings, therapeutic management, and outcomes. Prognosis mainly depends on the laryngeal squamous cell carcinoma, while papillary thyroid carcinoma generally…

K. Gorgi ^{1 *} M. Chaouche ² K. Rifai ¹ H. Iraqi ¹ M.H. Gharbi ¹

The association between primary hyperparathyroidism (PHPT) and non-medullary thyroid carcinoma is rare and is most often discovered incidentally during surgical exploration or histopathological examination. We report a case series of three patients presenting with thyroid carcinoma associated with primary hyperparathyroidism. We describe the clinical presentation, imaging findings, surgical management, and histopathological features. This coexistence raises pathophysiological questions and…

Nourhan Alsaeeid Alsaeeid ^{1 *}

IntroductionVentilator asynchrony is a frequent yet under-recognized problem in mechanically ventilated patients. Failure to detect asynchrony early may lead to prolonged ventilation, respiratory muscle weakness, and delayed rehabilitation. Recent advances in artificial intelligence have introduced smart camera and waveform-based systems capable of detecting subtle asynchrony patterns in real time Artificial Intelligence and Smart Monitoring Systems.

K. Gorgi ^{1 *} M. Chaouche ² K. Rifai ¹ H. Iraqi ¹ M.H. Gharbi ¹

Wolfram Syndrome (WS), also known as DIDMOAD (Diabetes Insipidus, Diabetes Mellitus, Optic Atrophy, and Deafness), is a rare neurodegenerative disorder [1, 2]. This condition features symptoms that typically appear progressively from childhood through adulthood [3, 4, 5]. Diagnosis is based on specific clinical criteria and confirmed by genetic testing for mutations in the WFS1 gene [6, 7]. Insulin therapy remains the mainstay treatment for diabetes mellitus, but incretin analogs may provide…

Amparo Leticia de la Fuente-Reynoso ^{1 *} Jennifer Dyall ¹ Laura Verónica Peña-Zermeño ¹ Agostino Menna ¹ Tom Adamyk ¹

Objective: The objective of this case study is to examine the effects of a structured Clinical Pilates (CP) intervention on functional mobility, balance, disability, quality of life, and selected biochemical markers in a 69-year-old male patient diagnosed with Idiopathic Inflammatory Myositis (IIM). Limited evidence regarding CP’s potential to improve functional mobility, balance, and psychosocial well-being in this population underscores the urgent need for exploratory,…

Zaparackaite I ¹ Govani ND ² Singh H ³ Singh SJ ⁴ Mehta AR ⁵ Midha PK ⁵ Patel R ² Patel RV ^{2 *}

Objectives: To synthesise current evidence on modified and extended anorectal myomectomy and transanal endosurgical procedures as diagnostic and therapeutic tools in congenital and acquired colorectal motility disordersand to clarify their role alongside manometry, radiology, and histopathology in contemporary clinical practice [1-4].

Design: Narrative review.

Data Sources: Peer-reviewed literature from PubMed,…

Govani DR ¹ Mehta AR ² Midha PK ³ Govani ND ¹ Panchasara NG ¹ Patel RR ¹ Patel RV ^{1 *}

This manuscript describes two exceptionally rare neonatal presentations of synchronous multiple neural tube defects (NTDs), involving separate thoracolumbar, lumbar, and sacral myelomeningoceles. We report two neonates presenting with synchronous dual and triple, open and closed spinal dysraphisms—distributed across thoracolumbar, lumbar, and sacral regions— without associated cranial defects. Both infants underwent early surgical repair. Case 1 demonstrated favorable early neurological…