Translational medicine areas include areas aimed at applying the results of basic research to develop new methods for diagnosing, treating and preventing diseases. The main areas of translational medicine are, firstly, personalized medicine - development of individual approaches to treatment based on the patient’s genetic, molecular and clinical information. Secondly, molecular diagnostics - creation of methods for identifying biomarkers and genetic markers of diseases for early diagnosis and...

Psoriasis is a chronic and burdensome skin disease that affects millions worldwide, and current biomedical research has uncovered complex genetic, immune, and environmental interactions underlying its pathology. These advances have improved symptom management through biologics and other therapies, but a true cure remains elusive, as treatments only suppress symptoms without addressing the root cause. Therefore, this study introduces the Buddhist perspective of Guan Yin Citta Dharma Door,...

Abstract: Enzymes are crucial biological catalysts that facilitate a wide array of biochemical reactions essential for life. The evolution and diversity of enzyme systems across species are central to understanding organismal adaptation and survival in varied environmental conditions. This paper explores the evolutionary mechanisms that drive the diversity of enzymes across different species, focusing on key enzyme families, metabolic pathways, and the role of genetic and...

Abstract: Sexual enzymes play a crucial role in regulating female reproductive and sexual health. These enzymes, including aromatase, phosphodiesterase type 5 (PDE5), hyaluronidase, lipoprotein lipase, and matrix metalloproteinases, are involved in various physiological processes that affect sexual arousal, lubrication, and tissue remodeling. Aromatase, for instance, regulates the conversion of androgens to estrogens, influencing libido and reproductive cycles. PDE5, while...

Abstract: Our DFT calculation provided the first theoretical investigation on Lewis/Brønsted acids-catalyzed syntheses of bicyclo[2.1.1]hexane and spirocyclic compound from disubstituted BCB and ester activated quinone. For [2π + 2σ] cycloaddition with Ni(OTf)2 , BCB was activated as nucleophile to attack quinone initially. Then bicyclic product was achieved via cyclization. For (3 + 2) cycloaddition with DTBP, the dehydrogenation of BCB and aromatization of quinone is...

Abstract: Infectious disease pose a significant worldwide fitness burden, exacerbated by the increasing prevalence of antimicrobial opposition (AMR). Traditional cures have utilized plant-derived compounds for a certain time, contributing to a promising alternative to artificial antimicrobials. This review surveys the role of plant-derivative antimicrobials in catching disease administration and emphasizes their mechanisms of operation, healing applications, and challenges....

Individuals' motivation to commit crime is often influenced by a confluence of factors such as mental health, emotional needs, economic status, social environment and family background. In addition, social factors such as social inequality, poverty, unemployment and social exclusion also play an important role in the formation of criminal motivation. An in-depth study of offenders' motivation can not only reveal the root causes of criminal behavior, but also provide a theoretical basis for...

Abstract: Attention-Deficit/Hyperactivity Disorder (ADHD) is a common neurodevelopmental disorder that affects children and can persist into adulthood, posing significant challenges in academic, social, and family settings. Pharmacological treatment remains one of the most widely used and effective approaches. In addition to medication, behavioral therapy has been proven effective in improving behavior and emotional regulation, and is often combined with medication for a more...

Abstract: Our DFT calculation provided the first theoretical investigation on Pd(OAc)2-catalyzed spiro cyclisation of sulfonamide with maleimide. Initially, Pd(OAc)2 is coordinated with quinoline leading to first N-Pd bond. Subsequently, via coordination of sulfonamide to Pd, the second N-Pd bond is generated after liberation of first acetic acid AcOH. Then C-Pd bond is formed by activation of γ-C(sp3)−H bond during formation of key five-membered ring intermediate together...

Abstract:This study aims to compare the applications and impacts of quantitative and qualitative research in the social sciences. Quantitative research, through the collection and statistical analysis of numerical data, can provide objective and reproducible results, making it suitable for large sample studies and hypothesis testing. Its strengths lie in the ability to conduct broad comparisons and inferences through quantitative indicators, while its limitations may include...