WebLog Journal of Endocrinology and Diabetes

Introduction Maturity Onset Diabetes of the Young (MODY) is a heterogeneous group of monogenic diabetes characterized by a primary defect in insulin secretion. It is a rare form of diabetes caused by autosomal dominant mutations, usually non-autoimmune and non-ketotic [1, 2]. The diagnosis of MODY is often overlooked in resource-limited countries, notably due to the frequent unavailability of genetic testing [3].

This study reports a series of 12 suspected MODY diabetes cases…

Latent autoimmune diabetes in adults (LADA) is an autoimmune form of diabetes situated between classical type 1 diabetes (T1D) and type 2 diabetes (T2D). It typically affects older adults and progresses more slowly toward insulin dependence. We report three cases of elderly female patients presenting with inaugural diabetic ketosis revealing slowly progressive type 1 diabetes. These observations highlight the diagnostic challenges and clinical features of this still poorly understood entity…

Introduction Familial hypercholesterolemia (FH) is an autosomal dominant genetic disorder caused by mutations in several genes involved in low-density lipoprotein (LDL) metabolism [1, 2]. It is characterized by an isolated increase in LDL cholesterol and is associated with a high risk of premature cardiovascular disease [3].

This condition is often underdiagnosed and undertreated, especially in resource-limited countries where genetic testing is less accessible…

Primary hyperparathyroidism corresponds to inappropriate overproduction of parathyroid hormone. It is a predominantly female disease and is often asymptomatic. Diagnosis is based solely on biological findings, and curative treatment is surgical.

This is a retrospective observational study including 83 patients hospitalized and followed for primary hyperparathyroidism in the endocrinology departments of the University Hospital Center of Rabat and Mohamed V Military Hospital over a…

Nelson’s syndrome is a severe complication that may develop in patients with Cushing’s disease treated with bilateral adrenalectomy. Since pituitary tumors in Nelson’s syndrome are often aggressive, early diagnosis and careful management are essential. We report three cases illustrating this syndrome.

Keywords: Nelson’s Syndrome; Pituitary Adenoma; Corticotroph Tumor; Adrenocorticotropic Hormone (ACTH); Bilateral Adrenalectomy; Cushing’s Disease;…

Brown tumors are bone manifestations of hyperparathyroidism (HPT). They usually occur in severe forms accompanied by signs of periosteal bone resorption. Their treatment mainly relies on parathyroidectomy.

We report a series of 9 cases of primary hyperparathyroidism revealed by a brown tumor. These clinical cases highlight the importance of phosphocalcic assessment in the presence of any bone swelling suggestive of a brown tumor.

Keywords: Brown Tumor;…

Oncocytic thyroid carcinoma is a rare tumor characterized by the proliferation of Hürthle (oncocytic) cells. It is an aggressive tumor and is insensitive to radioiodine therapy. We report a series of five patients diagnosed with oncocytic carcinoma.

Keywords: Oncocytic Carcinoma; Hürthle Cell Tumor; Total Thyroidectomy; Radioiodine Therapy

Diabetic ketoacidosis (DKA) is a frequent complication that generally evolves favorably; however, thromboembolic complications may occur. Pulmonary embolism is a rare complication. We report a series of five cases of type 1 diabetic female patients presenting with DKA complicated by thromboembolic disease, along with a review of the literature.

Keywords: Thrombosis; Hypercoagulability; Prophylactic Anticoagulation; Pulmonary Embolism

Type 2 diabetes (T2D) is a global health burden traditionally regarded as a metabolic disorder driven by insulin resistance, genetics, and lifestyle factors. Although scientific research has made considerable progress in identifying molecular mechanisms and therapeutic strategies, the disease is still widely considered irreversible. These approaches, however, overlook the deeper karmic origins of illness, which explain why patients are unable to restore normal pancreatic function or escape…

Type 2 diabetes (T2D) is a growing global health concern, characterized by insulin resistance, chronic hyperglycemia, and a range of associated complications. Traditional treatment regimens have largely focused on lifestyle changes and pharmacological interventions, but the search for novel therapeutic agents continues. Recent studies have explored the unique bioactive components of breast milk, which possess immunomodulatory, anti-inflammatory, and metabolic properties. Among these,…